About half of these are linked to a BRCA1 or BRCA2 gene mutation (BReast CAncer genes 1 and 2). People with a BRCA1/2 mutation have a greatly increased risk of breast cancer and (for women) ovarian cancer. The major breast cancer predisposing genes BRCA1 and BRCA2 were identified in and , respectively [1, 2].Unfortunately, the optimal clinical approach to women who develop hereditary breast cancer remains incompletely defined. Features of Hereditary Breast and Ovarian Cancer BRCA1/BRCA2 analysis may be appropriate if your personal and/or family history is suggestive of a hereditary predisposition to breast and ovarian cancer. This includes: • Breast cancer diagnosed under 50 years of age or triple negative breast cancer diagnosed under the age of 60 .